No, I didn’t mean Las Vegas! If you clicked to read about Autism link to Las Vegas, then you will be disappointed! 

Actually, I want to discuss the similarities of Vagus Nerve dysfunction (or our parasympathetic nervous system) and Autism traits. Also, we will look at the possibilities the how proper stimulation of the vagal nerve could help children on the Autism Spectrum Disorder!

Autism is not one disorder! It is a complex spectrum of varied etiology which mostly manifest in neurodevelopmental challenges. Autism affects almost 1 in every 50 children in the world. So if we extrapolate the last few years data, by 2050, we may have at least half of the Millennial population diagnosed with a spectrum disorder. Even with the growing body of research in all avenues of science, the cause remains unknown. 

Autism may be of scientific interest and solving this conundrum may be exciting for scientists, however, parents and caregivers often feel that they are in flux, as no one seems to really know what to do.


Last few years of technological advances, with Google at our fingertips, have exploded information into our lives. There seems to be an overload of information available to parents. However, sorting through and making sense of this information is like finding a needle in a haystack, especially if you find the wrong needle after all the effort you put in!

The availability of abundant information does not necessarily transfer into a good treatment. The problem I have found with this overload of information is that most of the information seems to have little or no scientific basis nor has it been researched well. Almost everyone seems to be an “Autism Expert” by the virtue of having heard or read about the term “Autism”. And everything seems to be ‘Miracle Cure for Autism’ luring parents into the trap of thinking that their child will be cured magically and possibly overnight.

A Magical cure for Autism is as preposterous as ‘Refrigerator Mother’ theory was when scientists blamed mothers being cold enough to cause ‘Autism’.

Autism isn’t one disorder, hence in my theory, maybe wrong (only time will tell!), is like an evolutionary step to human development.


In the last 30 years, we moved from being a community living to nuclear families. And now we have turned into reclusive individuals, and love spending time with our gadgets instead of family or friends. 

The evolution theory proves that the constant use or disuse for an organ or the processing of organs, can mutate and make the changes permanent over time. Evolution follows the ‘Use it or Lose it’ Law.

So use something consistently, we strengthen it, if we do not use it nor need it, eventually, we will lose it.  Sounds like something Nanny McPhee would say, Right?!

Before the advent of Mobile phones, people remembered everything. My dad still remembers all Birthdays, anniversaries, festivals, important dates, even calculates math mentally.  However, most people in “Mobile Generation” cannot remember their own schedules. To such an extent that many even needing a reminder for taking their pills and eating food on time!


According to Science, our body sends around 11 million pieces of information to our brain per second but our brain can only process 50 pieces of information every second!

So when we bombard it with irrelevant information from the latest social media craze,  you can only imagine what the brain’s processing center may look like! 

Coming back to our topic, in Autism, the Central Nervous System is definitely affected. Especially the amygdala, which is an important Vagus nerve stimulation (VNS) component of the neural network that underlies social cognition.


According to Neuroscientists and the Polyvagal Theory, “physiological mind-brain-viscera communication seems to be the road to affect regulation, hence we must also shift our therapeutic practice to help the dynamic changing interplay between sympathetic and parasympathetic nervous system”

“Several psychiatric and neurological disorders are characterized by difficulties in establishing and maintaining relationships, including difficulty both in expressing social behavior and in reading social cues (i.e., social awareness). Several psychiatric diagnoses are associated with specific deficits in both the behavioral (e.g., poor gaze, low facial affect, lack of prosody) and visceral (difficulties in autonomic regulation resulting in cardiopulmonary and digestive problems) components of the social engagement system.” – Polyvagal Theory (book)

Some major challenges that children with Autism and those with Vagal nerve Dysfunction seem to share are:

  1. Being unable to Self Regulate (affecting sleep/wake cycle and the bowel movements) 

Emotional Regulation (fluctuating extremes: emotional outbursts or lack of emotions)

  1. Social Engagement (connection with other people or being able to understand social cues)

  2. Neurohormonal Pathway regulation (Chronic Stress/anxiety triggers)

  3. Unable to regulate the pattern of voice stress and intonation (prosody) 

  4. Verbal Communication (speech delay or inability to process information for outcome)

  5. Chronic Inflammation (Vagus nerve is directly responsible to reduce inflammation)

  6. Gut and or Digestive Regulation (Vagal Nerve is responsible for carrying info to and from the brain and gut microbiome)

  7. Immune Regulation (the vagus nerve is a major constituent of a neural reflex mechanism—the inflammatory reflex—that controls innate immune responses and inflammation during pathogen invasion and tissue injury.)

Sensory Regulation (Sensory functions of the vagus nerve include: providing somatic sensation information for the skin behind the ear, the external part of the ear canal, and certain parts of the throat. supplying visceral sensation information for the larynx, esophagus, lungs, trachea, heart, and most of the digestive tract.)

We @ BrainAbility International, understand that helping activate and stimulate the vagus nerve and increasing vagal tone may help relieve many of the ‘Autism Symptoms’.

At BrainAbility International, through our Intensive Holistic Therapy #BAI Protocol, we work at naturally stimulating the parasympathetic Nervous system through our exercises and stimulating techniques. The combination of our #BAI protocol with our BAI Nutrition and BAI Multisensory Integration Intervention, works best, giving consistent and relatively quick improvement.

For more information please read our blogs or contact any of our centers in Bangalore, Pune or Agartala.


Abbott A. Neuroscience: the brain, interrupted. Nature. 2015;518:24–26.

Amaral, David & Corbett, Blythe. (2003). The amygdala, autism and anxiety. Novartis Foundation symposium. 251. 177-87; discussion 187. 

Bajbouj M, Merkl A, Schlaepfer TE, et al. Two-year outcome of vagus nerve stimulation in treatment-resistant depression. J Clin Psychopharmacol. 2010;30(3):273–281.

Bodenlos JS, Kose S, Borckardt JJ, et al. Vagus nerve stimulation acutely alters food craving in adults with depression. Appetite. 2007;48(2):145–153

Bonaz B, Bazin T, Pellissier S. The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis.Front Neuroscience. 2018 Feb 7;12:49. doi: 10.3389/fnins.2018.00049. 

Breit S, Kupferberg A, Rogler G, Hasler G. Vagus Nerve as a Modulator of the Brain-Gut Axis in Psychiatric and Inflammatory Disorders. Front Psychiatry. 2018;9:44. Published 2018 Mar 13. doi:10.3389/fpsyt.2018.00044

Breit S, Kupferberg A, Rogler G, Hasler G. Vagus nerve as a modulator of the brain-gut axis in psychiatric and inflammatory disorders. Front Psychiatry. 2018;9 10.3389/fpsyt.2018.00044.

Burneo JG, Faught E, Knowlton R, Morawetz R, Kuzniecky R. Weight loss associated with vagus nerve stimulation. Neurology. 2002;59(3):463–464.

Corbett, Blythe & Carmean, Vanessa & Ravizza, Susan & Wendelken, Carter & L Henry, Melissa & Carter, Cameron & Rivera, Susan. (2009). A functional and structural study of emotion and face processing in children with autism. Psychiatry research. 173. 196-205. 10.1016/j.pscychresns.2008.08.005. 

Corbett, Blythe & Schupp, Clayton & Simon, David & Ryan, Niles & Mendoza, Sally. (2010). Elevated cortisol during play is associated with age and social engagement in children with autism. Molecular autism. 1. 13. 10.1186/2040-2392-1-13. 

Cryan JF, O’Riordan KJ, Cowan CSM, Sandhu KV, Bastiaanssen TFS, Boehme M, Codagnone MG, Cussotto S, Fulling C, Golubeva AV, Guzzetta KE, Jaggar M, Long-Smith CM, Lyte JM, Martin JA, Molinero-Perez A, Moloney G, Morelli E, Morillas E, O’Connor R, Cruz-Pereira JS, Peterson VL, Rea K, Ritz NL, Sherwin E, Spichak S, Teichman EM, van de Wouw M, Ventura-Silva AP, Wallace-Fitzsimons SE, Hyland N, Clarke G, Dinan TG. “The Microbiota-Gut-Brain Axis”. Physiol Rev. 2019 Oct 1;99(4):1877-2013. doi:10.1152/physrev.00018.2018.

Dinan TG, Cryan GF. The impact of gut microbiota on brain and behavior: implications for psychiatry. Curr Opin Clin Nutr Metab Care. 2015;18:552–558.Dinan TG, Cryan JF. Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration. J Physiol. 2017 Jan 15;595(2):489-503. doi: 10.1113/JP273106. Epub 2016 Dec 4. Review.

Doheney KK, Palmer C, Browning KN, Jairath P, Liao D, He F, et al. Diminished vagal tone is a predictive biomarker of necrotizing enterocolitis-risk in preterm infants. Neurogastroenterol Motil. 2014;26:832–840

Egerod KL, Schwartz TW, Gautron L. The Molecular Diversity of Vagal Afferents  Revealed. Trends Neurosci. 2019 Aug 14. pii: S0166-2236(19)30135-3. Doi: 10.1016/j.tins.2019.08.002.

Egerod KL, Schwartz TW, Gautron L. The Molecular Diversity of Vagal Afferents  Revealed. Trends Neuroscience. 2019 Aug 14. pii: S0166-2236(19)30135-3. doi:


Engineer, Crystal T et al. “Vagus nerve stimulation as a potential adjuvant to behavioral therapy for autism and other neurodevelopmental disorders.”Journal of neurodevelopmental disorders vol. 9 20. 4 Jul. 2017, doi:10.1186/s11689-017-9203-z

Fan JJ, Shan W, Wu JP, Wang Q. Research progress of vagus nerve stimulation in the treatment of epilepsy. CNS Neurosci Ther. 2019 Aug 19. Doi: 10.1111/cns.13209

Field T, Diego M. Vagal activity, early growth and emotional development. Infant Behav Dev. 2008;31:361–373.

Forsythe PL, Bienenstock J, Kunze WA. Vagal pathways for microbiome-brain-gut axis communication. Adv Exp Med Biol. 2014;817:115–133.

Foster JA, Rinaman L, Cryan JF. Stress & the gut-brain axis: Regulation by the microbiome. Neurobiology Stress. 2017 Mar 19;7:124-136. Doi: 10.1016/j.ynstr.2017.03.001. eCollection 2017 Dec. Review.

Heiss CN, Olofsson LE. The role of the gut microbiota in development, function

and disorders of the central nervous system and the enteric nervous system. J

Neuroendocrinol. 2019 May;31(5):e12684. doi: 10.1111/jne.12684.

Hewitson, Laura & Lopresti, Brian & Stott, Carol & Mason, Neale & Tomko, Jaime. (2010). Influence of pediatric vaccines on amygdala growth and opioid ligand binding in rhesus macaque infants: A pilot study. Acta neurobiologiae experimentalis. 70. 147-64. 

Husain MM, Stegman D, Trevino K. Pregnancy and delivery while receiving vagus nerve stimulation for the treatment of major depression: a case report. Ann Gen Psychiatry. 2005;4:16.

Johnson RL, Wilson CG. A review of vagus nerve stimulation as a therapeutic intervention. J. Inflammation Res. 2018 May 16;11:203-213

Judkins A, Johnson RL, Murray ST, Yellon SM, Wilson CG. Vagus nerve stimulation in pregnant rats and effects on inflammatory markers in the brain stem of neonates. Pediatr Res. 2018;83(2):514–519

Kaniusas E, Kampusch S, Tittgemeyer M, Panetsos F, Gines RF, Papa M, Kiss A, Podesser B, Cassara AM, Tanghe E, Samoudi AM, Tarnaud T, Joseph W, Marozas V, Lukoševičius A, Ištuk N, Šarolić A, Lechner S, Klonowski W, Varaneckas G, Széles JC. Current Directions in the Auricular Vagus Nerve Stimulation I – A Physiological Perspective. Front Neurosciences. 2019 Aug 9;13:854. Doi: 10.3389/fnins.2019.00854. eCollection 2019. Review.

Kessler W, Diedrich S, Menges P, et al. The role of the vagus nerve: modulation of the inflammatory reaction in murine polymicrobial sepsis. Mediators Inflamm. 2012;2012:467620

Kinney DK, Barch DH, Chayka B, Napoleon S, Munir KM. Environmental risk factors for autism: do they help cause de novo genetic mutations that contribute to the disorder? Med Hypotheses. 2010;74:102–106

Kong, Jian et al. “Treating Depression with Transcutaneous Auricular Vagus Nerve Stimulation: State of the Art and Future Perspectives.”Frontiers in psychiatry vol. 9 20. 5 Feb. 2018, doi:10.3389/fpsyt.2018.00020

Koo B, Ham SD, Sood S, Tarver B. Human vagus nerve electrophysiology: a guide to vagus nerve stimulation parameters. J Clin Neurophysiol. 2001;18:429–433. doi: 10.1097/00004691-200109000-00007.

Levy ML, Levy KM, Hoff D, Amar AP, Park MS, Conklin JM, Baird L, Apuzzo ML. Vagus nerve stimulation therapy in patients with autism spectrum disorder and intractable epilepsy: results from the vagus nerve stimulation therapy patient outcome registry. J Neurosurg Pediatr. 2010 Jun;5(6):595-602.

Lovaas OI. Behavioral treatment and normal educational and intellectual functioning in young autistic children. J Consult Clin Psychol. 1987;55:3–9. doi: 10.1037/0022-006X.55.1.3.

Ma J, Qiao P, Li Q, Wang Y, Zhang L, Yan LJ, Cai Z. Vagus nerve stimulation as a promising adjunctive treatment for ischemic stroke. Neurochem Int. 2019 Aug 21;131:104539. doi: 10.1016/j.neuint.2019.104539.

Markram, Henry & Rinaldi, Tania & Markram, Kamila. (2007). The Intense World Syndrome – an Alternative Hypothesis for Autism.

Frontiers in neuroscience. 1. 77-96. 10.3389/neuro. Paintal AS. Vagal sensory receptors and their reflex effects. Physiol Rev. 1973 Jan;53(1):159-227. Review.

Pavlov VA, Tracey KJ. The vagus nerve and the inflammatory reflex—linking immunity. Nat Rev Endocrinol. 2012;8:743–754.

Russo R, Cristiano C, Avagliano C, De Caro C, La Rana G, Raso GM, Canani RB, Meli R, Calignano A. Gut-brain Axis: Role of Lipids in the Regulation of Inflammation, Pain and CNS Diseases. Curr Med Chem. 2018;25(32):3930-3952

Sajdel-Sulkowska, Elżbieta M et al. “Common Genetic Variants Link the Abnormalities in the Gut-Brain Axis in Prematurity and Autism.”Cerebellum (London, England) vol. 18,2 (2019): 255-265. doi:10.1007/s12311-018-0970-1

Silberstein SD, Mechtler LL, Kudrow DB, et al. Non-invasive vagus nerve stimulation for the acute treatment of cluster headache: findings from the randomized, double-blind, sham-controlled ACT1 study. Headache. 2016;56(8):1317–1332

Suess PE, Alpan G, Dulkerian SJ, Doussard-Roosevelt J, Porges SW, Gewolb IH. Respiratory sinus arrhythmia during feeding: a measure of vagal regulation of metabolism, ingestion, and digestion in preterm infants. Dev Med Child Neurol. 2000;42:169–173

Suller Marti A, Mirsattari SM, Steven DA, Parrent AG, MacDougall KW, McLachlan RS, Burneo JG. Experience on the use of Vagus Nerve Stimulation during pregnancy. Epilepsy Res. 2019 Aug 9;156:106186. doi: 10.1016/j.eplepsyres.2019.106186.

Supekar K, Menon V. Sex differences in the structural organization of motor systems and their dissociable links with repetitive/restricted behaviors in children with autism. Mol Autism. 2015;6:50.

Terra VC, Furlanetti LL, Nunes AA, Thomé U, Nisyiama MA, Sakamoto AC, et al. Vagus nerve stimulation in pediatric patients: is it really worthwhile? Epilepsy Behav. 2014;31:329–333. doi:

Val-Laillet D, Biraben A, Randuineau G, Malbert CH. Chronic vagus nerve stimulation decreased weight gain, food consumption and sweet craving in adult obese minipigs. Appetite. 2010;55(2):245–252

Whitaker-Azmitia, Patricia. (2005). Behavioral and cellular consequences of increasing serotonergic activity during brain development: A role in autism?. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 23. 75-83. 10.1016/j.ijdevneu.2004.07.022.